Close this search box.
The logo for Emerge Australia, centered around the keyword ME/CFS.
Close this search box.
Close this search box.
Close this search box.

Media and Research Digest (008)

Friday 10th August 2018
Welcome to the Eighth Emerge Australia Media and Research Digest!

The fortnightly summary of media and research about Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)

1 – Center for Disease Control updates ME/CFS  website content

It is widely recognised that many health care providers remain largely unaware of ME/CFS. In the United States it is estimated that information about ME/CFS is provided in less than a third of medical curriculums and less than half of all medical textbooks. This lack of education and awareness within the medical community means that patients often struggle with symptoms for extended periods of time before finally getting a diagnosis.

The Centers for Disease Control and Prevention (CDC) has now updated its website information about ME/CFS to guide clinicians on how to best help their patients to manage the illness. This is a big step forward for people with ME/CFS, and those campaigning for better awareness of the condition, as the CDC is a leading public health institute. It is hoped that this update will reach a large number of medical practitioners and improve rates of diagnosis for patients.

2  – Treating patients suffering from ME/CFS with Sodium Dichloroacetate
Author: Comhaire, F.

An open-label, proof-of-principle pilot trial from Belgium was recently done involving 22 patients diagnosed with ME/CFS. They were treated with a nutriceutical consisting of 400 mg of sodium salt of dichloroacetate (DCA) plus 100 mg Vitamin B1, with alfa-lipoic acid (ALA), acetyl-1-carnitine, and the oxidoreductase ubiquinone Q10. The aim of the study was to restore mitochondrial energy production, as suggested in hypotheses from other studies.

DCA inhibits the pyruvate dehydrogenase kinase (PDHk) and exerts a direct stimulatory effect on the activity of pyruvate dehydrogenase, which boosts mitochondrial function and increases production of adenosine triphosphate (ATP).

Trial results show that there was improvement in 10 patients, where their fatigue severity scale score reduced to almost half of that initially recorded. A number of co-morbidities were detected among the non-responders, which may affect the lack of response to nutriceutical treatment.

3 – Dr Shepherd provides an update on antibiotic use in ME and highlights concerns about quinolones and fluoroquinolones

Dr Charles Shepherd, medical adviser for the UK based ME Association, has stated a number of concerns regarding the use of quinolones and fluoroquinolones for ME/CFS patients as they may cause side effects involving muscles and tendons. Dr Shepherd acknowledges that antibiotics, when used correctly, are an effective way of dealing with infection. This is especially important for ME/CFS patients as infections can be an important cause for relapse.

However, a group of broad-spectrum antibiotics known as quinolones and fluoroquinolones can have adverse effects on pre-existing muscle disorders such as myasthenia gravis, as well as cause inflammation of the tendons (tendonitis). In addition to this, it is thought that these antibiotics act on the mitochondria and are reported to cause mitochondrial toxicity. The FDA has updated their warning related to these antibiotics to say “tendonitis, tendon rupture and irreversible nerve damage” and “risk of brain-related side-effects such as memory impairment, delirium, agitation and disorientation” might occur.

The ME Association is recommending that “ where an antibiotic is required to treat an infection that is not related to ME/CFS, doctors should only use one of these drugs after careful consideration and if there is no equally effective alternative drug for that infection”.

Share this page

Share This Article
Search Our Site

Read Previous Issues of Our Research Digest

Research Digest | Issue 107

Welcome to the 107th edition of Emerge Australia’s Research Digest, where we delve into recent research and media releases shaping our understanding of ME/CFS and

Read More »

Research Digest | Issue 106

Welcome to the 106th edition of Emerge Australia’s Digest. In this month’s issue, we explore literature that delves deeper into the connections between metabolic and

Read More »

Research Digest | Issue 105

Welcome to the 105th edition of Emerge Australia’s Digest. In this month’s issue, we delve into a single-cell RNA sequencing project aimed at understanding the

Read More »

Sign up to Stop. Rest. Pace.

Giving a voice to the unseen and unheard.
Sign up to our newsletter today.

Scroll to Top